"beneficial effects of vitamin c and vitamin e on blood pressure in hyperandrogenic women "

hyperandrogenism affects 2-6% of all women. hypertension is one of disturbances which is related to androgen excess. higher intakes of vitamin c and vitamin e have been associated with lower blood pressure. tho investigate the effect of these vitamin supplementation on blood pressure in hyperandrogenic women, a randomized, double-blind, placebo-controlled study was designed on 56 women 18-54 years old. women were randomly allocated to one of four treatment groups: spironolactone plus vitamain c and viamin e (sce), spironolactone plus vitamins placebo (sp), vitamin c plus vitamin e (ce), vitamins placebo (p). the treatment consisted of oral administration of 100 mg spironolactone, 1000 mg vitamin c and 900 mg vitamin e (alpha-tocopherol acetate) daily for about 3 months. results indicated that compared to pretreatment, vitamins supplementation significantly lowered systolic (119.1±12.6 vs. 112.6±15.4 mmhg) and mean blood pressure (97.4±11.5 vs. 92. ±12.1 mmhg) sce group (p<0.05), diastolic (87.3±12.7 vs. 80±12 mmhg) and mean group (p<0.05). blood levels of vitamin c and alpha-tocopherol increased in all sce and ce subjects. in conclusion, vitamin c and vitamin e supplementation reduced blood pressure in hperandrogenic women who are at risk of hypertension.